Bundesliga champions Bayern will be up against struggling Stuttgart at the Allianz Arena. However, Stuttgart may feel like it has a chance to cause an upset as Bayern had to travel to Milan to play its Champions League group stage match against Inter in midweek. The champions will be without winger Kingsley Coman, who sustained a muscle injury during training.
RB Leipzig will host Borussia Dortmund and the home team has a daunting task on its hands if it has to take points off the Bundesliga's early pace setters. Leipzig was thrashed at home by Shakhtar in the Champions League, and if form is anything to go by, Dortmund is likely to win the match comfortably. The home side will be missing talisman Dani Olmo in the attack, while its star man in defense, Josko Gvardiol, may also miss out with an abductor injury.
Bayer Leverkusen will travel to Hertha Berlin in a match that will pit two struggling teams against each other. The teams are currently sitting side by side in the standings, with Hertha Berlin in 14th place and Bayer Leverkusen in 15th place. For Hertha, new signing Agustin Rogel is set to make his Bundesliga debut. Bayer is likely to hand a first Bundesliga start to loan signing Callum Hudson Odoi. Last weekend, Hudson-Odoi made his first appearance in a Bayer shirt as a substitute and impressed.
Borussia Monchengladbach will play away to Bundesliga leaders SC Freiburg. It's set to be an exciting contest as both teams have impressed so far, even though Monchengladbach's attack has occasionally failed to fire. Freiburg will be missing Manuel Gulde and Rolland Salai, who still haven't recovered from the injuries they sustained in the clash against Leverkusen last week. Monchengladbach will see Ko Itakura serving a suspension due to his red card against Mainz. Attacker Alassane Plea is a doubt for the visitors as well.